Preheat oven to 425°F. Coat a 9x13-inch baking dish with gluten-free cooking spray.
In a large skillet, heat over medium-high, spray with cooking spray, and cook ground beef with salt until browned.
Add onion powder, garlic powder, and Italian seasoning.
Cook until beef is no longer pink, then drain fat.
Stir in pasta sauce and simmer for 5 minutes.
Remove from heat.
Prepare and drain spinach. In a bowl, combine spinach, ricotta (or hummus), and Parmesan (if using).
Spread 1 cup meat sauce in the baking dish.
Layer with 4 lasagna noodles, 1 cup sauce, 1/4 ricotta mixture, and 1/4 mozzarella.
Repeat layers three more times, ending with meat sauce and mozzarella.
Cover with greased foil and bake for 40 minutes.
Uncover and bake for an additional 20 minutes until browned and bubbly.
If noodles puff up, poke holes and press down with a spatula.
Rest lasagna for 10-15 minutes before cutting.